Endocrine Abstracts

Objective: This study aimed to compare US features and K-TIRADS categories for diagnosing isthmic and lobar PTCs.Methods: From January 2009 to December 2012, 163 patients who underwent thyroid surgery and were confirmed with a postoperative histopathological diagnosis of isthmic PTC were retrospectively included. Fifty-nine patients were excluded because their tumor size was < 0.5 cm, lack of preoperative thyroid US images, poor US image quality, and...

Introduction: The Wessex NET Group provides a dedicated NET dietitian service to patients across Dorset and Southern Hampshire. Patients receive individualised, evidence based advice by a dietitian with experience in the specific nutritional issues that NET patients experience. A patient questionnaire was implemented to assess the impact of the NET dietitian.Method: 212 confidential questionnaires were posted to all livi...

Background: Targeted therapy using phosphatidylinositol 3-kinase (PI3K) inhibitors has become widespread in the treatment of cancers. Although PI3K inhibitors raised concern about the alteration of glucose and lipid metabolism from animal studies, human clinical data have been rarely reported.Aim: We investigated the clinical manifestations, incidence of diabetes and its predictive factors in cancer patients who treated with PI3K inhibitors.<p class=...

Hydrochloric acid has been demonstrated to be important for the absorption of calcium and the bone loss is often seen in human after total gastrectomy. The aim of our study was to document the change of calcium and bone metabolism in the patients with decreased capacity of gastric acid secretion like chronic atrophic gastritis.The study sample consisted of chronic atrophic gastritis group and control group. Chronic atrophic gastritis group was 20 post-me...

Background: Previous studies show that lead levels are closely related with obesity, and severe weight reduction in obese women increases skeletal bone mobilization and blood lead levels especially postmenopausal women. However, it is under the curtain if blood lead level is associated with menopause, weight recycling in women until now.Methods: We assessed weight, height, waist circumferences and obtained past medical histories, blood lead levels as wel...

A 60 year old lady presented to her GP with symptoms, she described as ‘morning sickness’.She also reported nausea (better after eating), mild epigastric discomfort.Examination revealed a soft non tender abdomen, with no organomegaly.She was referred for urgent upper GI endoscopy and abdominal USS.Initial bloods showed impaired liver function,...

A 60 year old lady presented to her GP with symptoms, she described as ‘morning sickness’.She also reported nausea (better after eating), mild epigastric discomfort.Examination revealed a soft non tender abdomen, with no organomegaly.She was referred for urgent upper GI endoscopy and abdominal USS.Initial bloods showed impaired liver function,...

Tracheomalasia is extremely rare condition in Graves’ disease and may result in pneumomediastium with fistular formation from longstanding compression by a large goiter. There is no report that Graves’ disease combined with tracheomalasia and pneumomediastinum. A 24-year-old woman presented with abdominal pain, diarrhea and fever. On physical examination, a large goiter was detected on her anterior neck. Computed tomography of chest showed large amount of air in ante...

The estrogen receptor (ER) plays an important role in breast cancer development and progression. Hypoxia was shown to modulate the level of ERα expression and induce ligand-independent transcriptional activation of ERα, which may be intimately associated with the biology of breast carcinomas. Given that phosphorylation affects the transcriptional activity and stabilization of ERα, we examined the changes in phosphorylation of ERα under hypoxic conditions. H...

Menopausal status is associated with weight gain, increased central fat mass, abnormal lipid metabolism, insulin resistance, and susceptibility to metabolic syndrome (MetS). Leptin is synthesized and secreted by adipocytes. Serum leptin levels are highly correlated with fat mass. We determined the association between MetS and serum leptin levels in 153 postmenopausal women. The difference in serum leptin level between MetS and non-MetS groups showed a statistical significance ...